diff --git a/CHANGELOG.md b/CHANGELOG.md
index b8c5580ab..dd171daf6 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 ### Fixed
 
 - Don't reset horizontal padding on date/time pseudo-elements ([#14959](https://github.com/tailwindlabs/tailwindcss/pull/14959))
+- Don't emit `calc()` with invalid values for bare values that aren't integers in spacing utilities ([#14962](https://github.com/tailwindlabs/tailwindcss/pull/14962))
 
 ## [4.0.0-alpha.32] - 2024-11-11
 
diff --git a/packages/tailwindcss/src/utilities.test.ts b/packages/tailwindcss/src/utilities.test.ts
index a9c4a6ae2..3335e4168 100644
--- a/packages/tailwindcss/src/utilities.test.ts
+++ b/packages/tailwindcss/src/utilities.test.ts
@@ -3861,6 +3861,82 @@ test('translate-x', async () => {
       '-translate-x-[var(--value)]/foo',
     ]),
   ).toEqual('')
+
+  expect(
+    await compileCss(
+      css`
+        @theme {
+          --spacing: 0.25rem;
+        }
+        @tailwind utilities;
+      `,
+      ['translate-x-full', '-translate-x-full', 'translate-x-px', '-translate-x-[var(--value)]'],
+    ),
+  ).toMatchInlineSnapshot(`
+    ":root {
+      --spacing: .25rem;
+    }
+
+    .-translate-x-\\[var\\(--value\\)\\] {
+      --tw-translate-x: calc(var(--value) * -1);
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    .-translate-x-full {
+      --tw-translate-x: -100%;
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    .translate-x-full {
+      --tw-translate-x: 100%;
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    .translate-x-px {
+      --tw-translate-x: 1px;
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    @supports (-moz-orient: inline) {
+      @layer base {
+        *, :before, :after, ::backdrop {
+          --tw-translate-x: 0;
+          --tw-translate-y: 0;
+          --tw-translate-z: 0;
+        }
+      }
+    }
+
+    @property --tw-translate-x {
+      syntax: "<length> | <percentage>";
+      inherits: false;
+      initial-value: 0;
+    }
+
+    @property --tw-translate-y {
+      syntax: "<length> | <percentage>";
+      inherits: false;
+      initial-value: 0;
+    }
+
+    @property --tw-translate-z {
+      syntax: "<length>";
+      inherits: false;
+      initial-value: 0;
+    }"
+  `)
+  expect(
+    await run([
+      'perspective',
+      '-perspective',
+      'perspective-potato',
+      'perspective-123',
+      'perspective-normal/foo',
+      'perspective-dramatic/foo',
+      'perspective-none/foo',
+      'perspective-[456px]/foo',
+    ]),
+  ).toEqual('')
 })
 
 test('translate-y', async () => {
@@ -3933,6 +4009,82 @@ test('translate-y', async () => {
       '-translate-y-[var(--value)]/foo',
     ]),
   ).toEqual('')
+
+  expect(
+    await compileCss(
+      css`
+        @theme {
+          --spacing: 0.25rem;
+        }
+        @tailwind utilities;
+      `,
+      ['translate-y-full', '-translate-y-full', 'translate-y-px', '-translate-y-[var(--value)]'],
+    ),
+  ).toMatchInlineSnapshot(`
+    ":root {
+      --spacing: .25rem;
+    }
+
+    .-translate-y-\\[var\\(--value\\)\\] {
+      --tw-translate-y: calc(var(--value) * -1);
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    .-translate-y-full {
+      --tw-translate-y: -100%;
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    .translate-y-full {
+      --tw-translate-y: 100%;
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    .translate-y-px {
+      --tw-translate-y: 1px;
+      translate: var(--tw-translate-x) var(--tw-translate-y);
+    }
+
+    @supports (-moz-orient: inline) {
+      @layer base {
+        *, :before, :after, ::backdrop {
+          --tw-translate-x: 0;
+          --tw-translate-y: 0;
+          --tw-translate-z: 0;
+        }
+      }
+    }
+
+    @property --tw-translate-x {
+      syntax: "<length> | <percentage>";
+      inherits: false;
+      initial-value: 0;
+    }
+
+    @property --tw-translate-y {
+      syntax: "<length> | <percentage>";
+      inherits: false;
+      initial-value: 0;
+    }
+
+    @property --tw-translate-z {
+      syntax: "<length>";
+      inherits: false;
+      initial-value: 0;
+    }"
+  `)
+  expect(
+    await run([
+      'perspective',
+      '-perspective',
+      'perspective-potato',
+      'perspective-123',
+      'perspective-normal/foo',
+      'perspective-dramatic/foo',
+      'perspective-none/foo',
+      'perspective-[456px]/foo',
+    ]),
+  ).toEqual('')
 })
 
 test('translate-z', async () => {
diff --git a/packages/tailwindcss/src/utilities.ts b/packages/tailwindcss/src/utilities.ts
index 96ceea6b5..a20938550 100644
--- a/packages/tailwindcss/src/utilities.ts
+++ b/packages/tailwindcss/src/utilities.ts
@@ -387,6 +387,8 @@ export function createUtilities(theme: Theme) {
       handleNegativeBareValue: ({ value }) => {
         let multiplier = theme.resolve(null, ['--spacing'])
         if (!multiplier) return null
+        if (!isValidSpacingMultiplier(value)) return null
+
         return `calc(${multiplier} * -${value})`
       },
       handle,
diff --git a/playgrounds/vite/src/app.tsx b/playgrounds/vite/src/app.tsx
index 8ec502989..4abc17cb5 100644
--- a/playgrounds/vite/src/app.tsx
+++ b/playgrounds/vite/src/app.tsx
@@ -2,6 +2,7 @@ export function App() {
   return (
     <div className="m-3 p-3 border">
       <h1 className="text-blue-500">Hello World</h1>
+      <div className="-inset-x-full -inset-y-full -space-x-full -space-y-full -inset-full"></div>
     </div>
   )
 }