diff --git a/CHANGELOG.md b/CHANGELOG.md
index 4a2aecbc2..b97a201df 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -15,6 +15,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - Discard invalid `variants` and `utilities` with modifiers ([#13977](https://github.com/tailwindlabs/tailwindcss/pull/13977))
 - Add missing utilities that exist in v3, such as `resize`, `fill-none`, `accent-none`, `drop-shadow-none`, and negative `hue-rotate` and `backdrop-hue-rotate` utilities ([#13971](https://github.com/tailwindlabs/tailwindcss/pull/13971))
 - Don’t allow at-rule-only variants to be compounded ([#14015](https://github.com/tailwindlabs/tailwindcss/pull/14015))
+- Ensure compound variants work with variants with multiple selectors ([#14016](https://github.com/tailwindlabs/tailwindcss/pull/14016))
 
 ### Added
 
diff --git a/packages/tailwindcss/src/variants.test.ts b/packages/tailwindcss/src/variants.test.ts
index e22b0a953..2955e415c 100644
--- a/packages/tailwindcss/src/variants.test.ts
+++ b/packages/tailwindcss/src/variants.test.ts
@@ -738,12 +738,25 @@ test('group-[...]', () => {
 
 test('group-*', () => {
   expect(
-    run([
-      'group-hover:flex',
-      'group-focus:flex',
-      'group-hover:group-focus:flex',
-      'group-focus:group-hover:flex',
-    ]),
+    compileCss(
+      css`
+        @variant hocus {
+          &:hover,
+          &:focus {
+            @slot;
+          }
+        }
+        @tailwind utilities;
+      `,
+      [
+        'group-hover:flex',
+        'group-focus:flex',
+        'group-hocus:flex',
+
+        'group-hover:group-focus:flex',
+        'group-focus:group-hover:flex',
+      ],
+    ),
   ).toMatchInlineSnapshot(`
     ".group-hover\\:flex:is(:where(.group):hover *) {
       display: flex;
@@ -759,6 +772,10 @@ test('group-*', () => {
 
     .group-hover\\:group-focus\\:flex:is(:where(.group):hover *):is(:where(.group):focus *) {
       display: flex;
+    }
+
+    .group-hocus\\:flex:is(:is(:where(.group):hover, :where(.group):focus) *) {
+      display: flex;
     }"
   `)
 
@@ -816,12 +833,24 @@ test('peer-[...]', () => {
 
 test('peer-*', () => {
   expect(
-    run([
-      'peer-hover:flex',
-      'peer-focus:flex',
-      'peer-hover:peer-focus:flex',
-      'peer-focus:peer-hover:flex',
-    ]),
+    compileCss(
+      css`
+        @variant hocus {
+          &:hover,
+          &:focus {
+            @slot;
+          }
+        }
+        @tailwind utilities;
+      `,
+      [
+        'peer-hover:flex',
+        'peer-focus:flex',
+        'peer-hocus:flex',
+        'peer-hover:peer-focus:flex',
+        'peer-focus:peer-hover:flex',
+      ],
+    ),
   ).toMatchInlineSnapshot(`
     ".peer-hover\\:flex:is(:where(.peer):hover ~ *) {
       display: flex;
@@ -837,6 +866,10 @@ test('peer-*', () => {
 
     .peer-hover\\:peer-focus\\:flex:is(:where(.peer):hover ~ *):is(:where(.peer):focus ~ *) {
       display: flex;
+    }
+
+    .peer-hocus\\:flex:is(:is(:where(.peer):hover, :where(.peer):focus) ~ *) {
+      display: flex;
     }"
   `)
 
@@ -1502,19 +1535,39 @@ test('supports', () => {
 
 test('not', () => {
   expect(
-    run([
-      'not-[:checked]:flex',
+    compileCss(
+      css`
+        @variant hocus {
+          &:hover,
+          &:focus {
+            @slot;
+          }
+        }
+        @tailwind utilities;
+      `,
+      [
+        'not-[:checked]:flex',
+        'not-hocus:flex',
 
-      'group-not-[:checked]:flex',
-      'group-not-[:checked]/parent-name:flex',
-      'group-not-checked:flex',
+        'group-not-[:checked]:flex',
+        'group-not-[:checked]/parent-name:flex',
+        'group-not-checked:flex',
+        'group-not-hocus:flex',
+        'group-not-hocus/parent-name:flex',
 
-      'peer-not-[:checked]:flex',
-      'peer-not-[:checked]/parent-name:flex',
-      'peer-not-checked:flex',
-    ]),
+        'peer-not-[:checked]:flex',
+        'peer-not-[:checked]/sibling-name:flex',
+        'peer-not-checked:flex',
+        'peer-not-hocus:flex',
+        'peer-not-hocus/sibling-name:flex',
+      ],
+    ),
   ).toMatchInlineSnapshot(`
-    ".not-\\[\\:checked\\]\\:flex:not(:checked) {
+    ".not-hocus\\:flex:not(:hover, :focus) {
+      display: flex;
+    }
+
+    .not-\\[\\:checked\\]\\:flex:not(:checked) {
       display: flex;
     }
 
@@ -1522,6 +1575,14 @@ test('not', () => {
       display: flex;
     }
 
+    .group-not-hocus\\:flex:is(:where(.group):not(:hover, :focus) *) {
+      display: flex;
+    }
+
+    .group-not-hocus\\/parent-name\\:flex:is(:where(.group\\/parent-name):not(:hover, :focus) *) {
+      display: flex;
+    }
+
     .group-not-\\[\\:checked\\]\\:flex:is(:where(.group):not(:checked) *) {
       display: flex;
     }
@@ -1534,11 +1595,19 @@ test('not', () => {
       display: flex;
     }
 
+    .peer-not-hocus\\:flex:is(:where(.peer):not(:hover, :focus) ~ *) {
+      display: flex;
+    }
+
+    .peer-not-hocus\\/sibling-name\\:flex:is(:where(.peer\\/sibling-name):not(:hover, :focus) ~ *) {
+      display: flex;
+    }
+
     .peer-not-\\[\\:checked\\]\\:flex:is(:where(.peer):not(:checked) ~ *) {
       display: flex;
     }
 
-    .peer-not-\\[\\:checked\\]\\/parent-name\\:flex:is(:where(.peer\\/parent-name):not(:checked) ~ *) {
+    .peer-not-\\[\\:checked\\]\\/sibling-name\\:flex:is(:where(.peer\\/sibling-name):not(:checked) ~ *) {
       display: flex;
     }"
   `)
@@ -1556,22 +1625,46 @@ test('not', () => {
 
 test('has', () => {
   expect(
-    run([
-      'has-[:checked]:flex',
+    compileCss(
+      css`
+        @variant hocus {
+          &:hover,
+          &:focus {
+            @slot;
+          }
+        }
+        @tailwind utilities;
+      `,
+      [
+        'has-[:checked]:flex',
+        'has-hocus:flex',
 
-      'group-has-[:checked]:flex',
-      'group-has-[:checked]/parent-name:flex',
-      'group-has-checked:flex',
+        'group-has-[:checked]:flex',
+        'group-has-[:checked]/parent-name:flex',
+        'group-has-checked:flex',
+        'group-has-hocus:flex',
+        'group-has-hocus/parent-name:flex',
 
-      'peer-has-[:checked]:flex',
-      'peer-has-[:checked]/sibling-name:flex',
-      'peer-has-checked:flex',
-    ]),
+        'peer-has-[:checked]:flex',
+        'peer-has-[:checked]/sibling-name:flex',
+        'peer-has-checked:flex',
+        'peer-has-hocus:flex',
+        'peer-has-hocus/sibling-name:flex',
+      ],
+    ),
   ).toMatchInlineSnapshot(`
     ".group-has-checked\\:flex:is(:where(.group):has(:checked) *) {
       display: flex;
     }
 
+    .group-has-hocus\\:flex:is(:where(.group):has(:hover, :focus) *) {
+      display: flex;
+    }
+
+    .group-has-hocus\\/parent-name\\:flex:is(:where(.group\\/parent-name):has(:hover, :focus) *) {
+      display: flex;
+    }
+
     .group-has-\\[\\:checked\\]\\:flex:is(:where(.group):has(:checked) *) {
       display: flex;
     }
@@ -1584,6 +1677,14 @@ test('has', () => {
       display: flex;
     }
 
+    .peer-has-hocus\\:flex:is(:where(.peer):has(:hover, :focus) ~ *) {
+      display: flex;
+    }
+
+    .peer-has-hocus\\/sibling-name\\:flex:is(:where(.peer\\/sibling-name):has(:hover, :focus) ~ *) {
+      display: flex;
+    }
+
     .peer-has-\\[\\:checked\\]\\:flex:is(:where(.peer):has(:checked) ~ *) {
       display: flex;
     }
@@ -1592,6 +1693,10 @@ test('has', () => {
       display: flex;
     }
 
+    .has-hocus\\:flex:has(:hover, :focus) {
+      display: flex;
+    }
+
     .has-\\[\\:checked\\]\\:flex:has(:checked) {
       display: flex;
     }"
diff --git a/packages/tailwindcss/src/variants.ts b/packages/tailwindcss/src/variants.ts
index c3c50bc63..3611dd0b3 100644
--- a/packages/tailwindcss/src/variants.ts
+++ b/packages/tailwindcss/src/variants.ts
@@ -216,7 +216,7 @@ export function createVariants(theme: Theme): Variants {
 
       // Replace `&` in target variant with `*`, so variants like `&:hover`
       // become `&:not(*:hover)`. The `*` will often be optimized away.
-      node.selector = `&:not(${node.selector.replace('&', '*')})`
+      node.selector = `&:not(${node.selector.replaceAll('&', '*')})`
 
       // Track that the variant was actually applied
       didApply = true
@@ -442,7 +442,7 @@ export function createVariants(theme: Theme): Variants {
 
       // Replace `&` in target variant with `*`, so variants like `&:hover`
       // become `&:has(*:hover)`. The `*` will often be optimized away.
-      node.selector = `&:has(${node.selector.replace('&', '*')})`
+      node.selector = `&:has(${node.selector.replaceAll('&', '*')})`
 
       // Track that the variant was actually applied
       didApply = true