diff --git a/jerry-core/ecma/operations/ecma-bigint.c b/jerry-core/ecma/operations/ecma-bigint.c
index dfb9d2c2a..216d6d570 100644
--- a/jerry-core/ecma/operations/ecma-bigint.c
+++ b/jerry-core/ecma/operations/ecma-bigint.c
@@ -1412,6 +1412,11 @@ ecma_bigint_shift (ecma_value_t left_value, /**< left BigInt value */
     {
       return ecma_bigint_raise_memory_error ();
     }
+    else if (left_p->u.bigint_sign_and_size & ECMA_BIGINT_SIGN)
+    {
+      /* Shifting a negative value with a very big number to the right should be -1. */
+      return ecma_bigint_create_from_digit (1, true);
+    }
 
     return ECMA_BIGINT_ZERO;
   }
diff --git a/tests/jerry/es.next/regression-test-issue-4341.js b/tests/jerry/es.next/regression-test-issue-4341.js
new file mode 100644
index 000000000..28ab43aa6
--- /dev/null
+++ b/tests/jerry/es.next/regression-test-issue-4341.js
@@ -0,0 +1,47 @@
+// Copyright JS Foundation and other contributors, http://js.foundation
+//
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+//     http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+
+/* Shifting a negative bigint value with a big number to the right should be -1n. */
+assert((-1n >> (2n ** 32n)) === -1n);
+assert((-1n >> 2n) === -1n);
+assert((-1n >> (2n ** 1n)) === -1n);
+assert((-5n >> 3n) === -1n);
+assert((-5n >> 4n) === -1n);
+assert((-(2n ** 32n) >> (2n ** 31n)) === -1n);
+assert((-(2n ** 32n) >> (2n ** 32n)) === -1n);
+assert((-(2n ** 32n) >> (2n ** 33n)) === -1n);
+assert((-(2n ** 32n) >> (2n ** 33000n)) === -1n);
+assert((-(2n ** 32n) >> 32n) === -1n);
+
+/* (xn << -yn) ==> (xn >> yn) */
+assert((-1n << -(2n ** 32n)) === -1n);
+assert((-1n << -2n) === -1n);
+assert((-1n << -(2n ** 1n)) === -1n);
+assert((-5n << -3n) === -1n);
+assert((-5n << -4n) === -1n);
+assert((-(2n ** 32n) << -(2n ** 31n)) === -1n);
+assert((-(2n ** 32n) << -(2n ** 32n)) === -1n);
+assert((-(2n ** 32n) << -(2n ** 33n)) === -1n);
+assert((-(2n ** 32n) << -(2n ** 33000n)) === -1n);
+
+/* Partialy related tests. */
+assert((-(2n ** 32n) >> 31n) === -2n);
+assert((-(2n ** 32n) >> 30n) === -4n);
+assert((-(2n ** 32n) >> 29n) === -8n);
+assert((-(2n ** 32n) >> 28n) === -16n);
+assert((-(2n ** 32n) >> 16n) === -65536n);
+assert((-(2n ** 32n) >> 2n) === -1073741824n);
+
+assert((-5n >> 2n) === -2n);
+assert((-5n >> -4n) === -80n);