diff --git a/packages/grpc-js/src/call-stream.ts b/packages/grpc-js/src/call-stream.ts
index 8fcc7065..3a81cbe9 100644
--- a/packages/grpc-js/src/call-stream.ts
+++ b/packages/grpc-js/src/call-stream.ts
@@ -70,6 +70,17 @@ function getSystemErrorName(errno: number): string {
 
 export type Deadline = Date | number;
 
+function getMinDeadline(deadlineList: Deadline[]): Deadline {
+  let minValue: number = Infinity;
+  for (const deadline of deadlineList) {
+    const deadlineMsecs = deadline instanceof Date ? deadline.getTime() : deadline;
+    if (deadlineMsecs < minValue) {
+      minValue = deadlineMsecs;
+    }
+  }
+  return minValue;
+}
+
 export interface CallStreamOptions {
   deadline: Deadline;
   flags: number;
@@ -235,6 +246,8 @@ export class Http2CallStream implements Call {
 
   private internalError: SystemError | null = null;
 
+  private configDeadline: Deadline = Infinity;
+
   constructor(
     private readonly methodName: string,
     private readonly channel: ChannelImplementation,
@@ -675,15 +688,14 @@ export class Http2CallStream implements Call {
   }
 
   getDeadline(): Deadline {
+    const deadlineList = [this.options.deadline];
     if (this.options.parentCall && this.options.flags & Propagate.DEADLINE) {
-      const parentDeadline = this.options.parentCall.getDeadline();
-      const selfDeadline = this.options.deadline;
-      const parentDeadlineMsecs = parentDeadline instanceof Date ? parentDeadline.getTime() : parentDeadline;
-      const selfDeadlineMsecs = selfDeadline instanceof Date ? selfDeadline.getTime() : selfDeadline;
-      return Math.min(parentDeadlineMsecs, selfDeadlineMsecs);
-    } else {
-      return this.options.deadline;
+      deadlineList.push(this.options.parentCall.getDeadline());
     }
+    if (this.configDeadline) {
+      deadlineList.push(this.configDeadline);
+    }
+    return getMinDeadline(deadlineList);
   }
 
   getCredentials(): CallCredentials {
@@ -710,6 +722,10 @@ export class Http2CallStream implements Call {
     return this.options.host;
   }
 
+  setConfigDeadline(configDeadline: Deadline) {
+    this.configDeadline = configDeadline;
+  }
+
   startRead() {
     /* If the stream has ended with an error, we should not emit any more
      * messages and we should communicate that the stream has ended */
diff --git a/packages/grpc-js/src/channel.ts b/packages/grpc-js/src/channel.ts
index 41715c41..8b2658f3 100644
--- a/packages/grpc-js/src/channel.ts
+++ b/packages/grpc-js/src/channel.ts
@@ -509,6 +509,11 @@ export class ChannelImplementation implements Channel {
   }
 
   private tryGetConfig(stream: Http2CallStream, metadata: Metadata) {
+    if (stream.getStatus() !== null) {
+      /* If the stream has a status, it has already finished and we don't need
+       * to take any more actions on it. */
+      return;
+    }
     if (this.configSelector === null) {
       /* This branch will only be taken at the beginning of the channel's life,
        * before the resolver ever returns a result. So, the
@@ -523,6 +528,14 @@ export class ChannelImplementation implements Channel {
     } else {
       const callConfig = this.configSelector(stream.getMethod(), metadata);
       if (callConfig.status === Status.OK) {
+        if (callConfig.methodConfig.timeout) {
+          const deadline = new Date();
+          deadline.setSeconds(deadline.getSeconds() + callConfig.methodConfig.timeout.seconds);
+          deadline.setMilliseconds(deadline.getMilliseconds() + callConfig.methodConfig.timeout.nanos / 1_000_000);
+          stream.setConfigDeadline(deadline);
+          // Refreshing the filters makes the deadline filter pick up the new deadline
+          stream.filterStack.refresh();
+        }
         this.tryPick(stream, metadata, callConfig);
       } else {
         stream.cancelWithStatus(callConfig.status, "Failed to route call to method " + stream.getMethod());
diff --git a/packages/grpc-js/src/deadline-filter.ts b/packages/grpc-js/src/deadline-filter.ts
index 99bfa2be..afc01554 100644
--- a/packages/grpc-js/src/deadline-filter.ts
+++ b/packages/grpc-js/src/deadline-filter.ts
@@ -42,30 +42,41 @@ function getDeadline(deadline: number) {
 
 export class DeadlineFilter extends BaseFilter implements Filter {
   private timer: NodeJS.Timer | null = null;
-  private deadline: number;
+  private deadline: number = Infinity;
   constructor(
     private readonly channel: Channel,
     private readonly callStream: Call
   ) {
     super();
-    const callDeadline = callStream.getDeadline();
+    this.retreiveDeadline();
+    this.runTimer();
+  }
+
+  private retreiveDeadline() {
+    const callDeadline = this.callStream.getDeadline();
     if (callDeadline instanceof Date) {
       this.deadline = callDeadline.getTime();
     } else {
       this.deadline = callDeadline;
     }
+  }
+
+  private runTimer() {
+    if (this.timer) {
+      clearTimeout(this.timer);
+    }
     const now: number = new Date().getTime();
     let timeout = this.deadline - now;
     if (timeout <= 0) {
       process.nextTick(() => {
-        callStream.cancelWithStatus(
+        this.callStream.cancelWithStatus(
           Status.DEADLINE_EXCEEDED,
           'Deadline exceeded'
         );
       });
     } else if (this.deadline !== Infinity) {
       this.timer = setTimeout(() => {
-        callStream.cancelWithStatus(
+        this.callStream.cancelWithStatus(
           Status.DEADLINE_EXCEEDED,
           'Deadline exceeded'
         );
@@ -74,6 +85,11 @@ export class DeadlineFilter extends BaseFilter implements Filter {
     }
   }
 
+  refresh() {
+    this.retreiveDeadline();
+    this.runTimer();
+  }
+
   async sendMetadata(metadata: Promise<Metadata>) {
     if (this.deadline === Infinity) {
       return metadata;
diff --git a/packages/grpc-js/src/filter-stack.ts b/packages/grpc-js/src/filter-stack.ts
index a656a409..4fd88854 100644
--- a/packages/grpc-js/src/filter-stack.ts
+++ b/packages/grpc-js/src/filter-stack.ts
@@ -71,6 +71,12 @@ export class FilterStack implements Filter {
 
     return result;
   }
+
+  refresh(): void {
+    for (const filter of this.filters) {
+      filter.refresh();
+    }
+  }
 }
 
 export class FilterStackFactory implements FilterFactory<FilterStack> {
diff --git a/packages/grpc-js/src/filter.ts b/packages/grpc-js/src/filter.ts
index c1e412ae..eb67bd32 100644
--- a/packages/grpc-js/src/filter.ts
+++ b/packages/grpc-js/src/filter.ts
@@ -32,6 +32,8 @@ export interface Filter {
   receiveMessage(message: Promise<Buffer>): Promise<Buffer>;
 
   receiveTrailers(status: StatusObject): StatusObject;
+
+  refresh(): void;
 }
 
 export abstract class BaseFilter implements Filter {
@@ -54,6 +56,9 @@ export abstract class BaseFilter implements Filter {
   receiveTrailers(status: StatusObject): StatusObject {
     return status;
   }
+
+  refresh(): void {
+  }
 }
 
 export interface FilterFactory<T extends Filter> {
diff --git a/packages/grpc-js/src/service-config.ts b/packages/grpc-js/src/service-config.ts
index ed225e08..efc09f9c 100644
--- a/packages/grpc-js/src/service-config.ts
+++ b/packages/grpc-js/src/service-config.ts
@@ -34,10 +34,15 @@ export interface MethodConfigName {
   method?: string;
 }
 
+export interface Duration {
+  seconds: number;
+  nanos: number;
+}
+
 export interface MethodConfig {
   name: MethodConfigName[];
   waitForReady?: boolean;
-  timeout?: string;
+  timeout?: Duration;
   maxRequestBytes?: number;
   maxResponseBytes?: number;
 }
@@ -101,13 +106,25 @@ function validateMethodConfig(obj: any): MethodConfig {
     result.waitForReady = obj.waitForReady;
   }
   if ('timeout' in obj) {
-    if (
-      !(typeof obj.timeout === 'string') ||
-      !TIMEOUT_REGEX.test(obj.timeout)
+    if (typeof obj.timeout === 'object') {
+      if (!('seconds' in obj.timeout) || !(typeof obj.timeout.seconds === 'number')) {
+        throw new Error('Invalid method config: invalid timeout.seconds');
+      }
+      if (!('nanos' in obj.timeout) || !(typeof obj.timeout.nanos === 'number')) {
+        throw new Error('Invalid method config: invalid timeout.nanos');
+      }
+      result.timeout = obj.timeout;
+    } else if (
+      (typeof obj.timeout === 'string') && TIMEOUT_REGEX.test(obj.timeout)
     ) {
+      const timeoutParts = obj.timeout.substring(0, obj.timeout.length - 1).split('.');
+      result.timeout = {
+        seconds: timeoutParts[0] | 0,
+        nanos: (timeoutParts[1] ?? 0) | 0
+      }
+    } else {
       throw new Error('Invalid method config: invalid timeout');
     }
-    result.timeout = obj.timeout;
   }
   if ('maxRequestBytes' in obj) {
     if (typeof obj.maxRequestBytes !== 'number') {